Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs

19 Oct 2016

Abstract excerpt

The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer's dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B12, methionine and homocysteine. However, the existence or physiological significance of this phenomenon has been unknown in bacteria, which synthesize folate de novo. Here we identify the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folate and B Vitamins Research
Share to Porphyrin Metabolism and Disorders
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27760199
DOI: 10.1371/journal.ppat.1005949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa DrugsPMID 27760199Read ↗

Mechanisms of Staphylococcus aureus survival of trimethoprim-sulfamethoxazole-induced thymineless death.Semantic proximity Read ↗

Essential Metabolic Routes as a Way to ESKAPE From Antibiotic ResistanceSemantic proximity Read ↗

Essential Metabolic Routes as a Way to ESKAPE from Antibiotic ResistanceSemantic proximity Read ↗

A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targetingSemantic proximity Read ↗

Tellurite-dependent blackening of bacteria emerges from the dark agesSemantic proximity Read ↗

A bifunctional salvage pathway for two distinct S‐adenosylmethionine by‐products that is widespread in bacteria, including pathogenic Escherichia coliSemantic proximity Read ↗

Bacterial conversion of folinic acid is required for antifolate resistance.Semantic proximity Read ↗

Mechanisms of folate metabolism-related substances affecting Staphylococcus aureus infectionSemantic proximity Read ↗

Systems metabolic engineering of Bacillus subtilis for efficient biosynthesis of 5‐methyltetrahydrofolateSemantic proximity Read ↗

Essential roles of methionine and <i>S</i> -adenosylmethionine in the autarkic lifestyle of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Pyrimidine Analogues as a New Class of Gram-Positive Antibiotics, Mainly Targeting Thymineless-Death Related ProteinsSemantic proximity Read ↗

Elucidation of an anaerobic pathway for metabolism of L-carnitine-derived γ-butyrobetaine to trimethylamine in human gut bacteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.