Article

High Throughput Assessment of Gut Bacterial Tyrosine Decarboxylase Activity for Predicting Peripheral Levodopa Loss in Parkinson's Disease

2023-09-08

Abstract excerpt

<title>Abstract</title> <p>Parkinson's disease (PD), a prevalent neurodegenerative disorder, is commonly managed through oral levodopa administration. However, the enzymatic activity of specific gut bacteria, particularly tyrosine decarboxylase (TDC), can metabolize levodopa, potentially leading to diminishing treatment effectiveness over time. Current methods for assessing TDC activity in PD patients focus mainl...

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Literature Corpus work: 70b794b2-89d1-5076-aea5-d0cc1dafc662
DOI: 10.21203/rs.3.pex-2347/v1

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