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Article

An engineered dual-functional L-DOPA decarboxylase enables a minimized hydroxytyrosol cascade.

International journal of biological macromolecules - 1 Jan 2025

Tang Shiming, Ouyang Zhilin, Huo Ying, Liao Daocheng, Zhang Zhiteng, Lin Ying, Zheng Suiping

Abstract excerpt

Hydroxytyrosol has been proven beneficial to human health. However, the process involving the conversion of L-DOPA to 3,4-dihydroxyphenylacetaldehyde (3,4-DHPAA) in hydroxytyrosol biosynthesis typically required the simultaneous use of decarboxylase and oxidative deaminase. In addition, phenylacetaldehyde reductase from Solanum lycopersicum (SlPAR) in hydroxytyrosol biosynthesis exhibits poor thermal stability....

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PMID: 39615727
DOI: 10.1016/j.ijbiomac.2024.138176

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