Article

Gut bacterial tyrosine decarboxylase gene abundance associates with disease duration, medication exposure, and gastrointestinal symptoms in a longitudinal cohort of Parkinson’s disease patients

2021-07-15

Abstract excerpt

Gut microbiota influences the clinical response of a wide variety of orally administered drugs. However, the underlying mechanisms by which drug-microbiota interactions occur are still obscure. Previously, we reported that tyrosine decarboxylating (TDC) bacteria may restrict the levels of levodopa reaching the circulation in patients with Parkinson’s disease (PD). We observed a significant positive association bet...

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Literature Corpus work: 2523c308-3001-5f03-bf7c-1e6ccb90d75f
DOI: 10.1101/2021.07.13.21259300

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