Article
SARS-CoV-2 genomic diversity and within-host evolution in individuals with persistent infection in the UK: an observational, longitudinal, population-based surveillance study.
The Lancet. Microbe - 1 Sept 2025
Ghafari Mahan, Kemp Steven A, Hall Matthew, Clarke Joseph, Ferretti Luca, Thomson Laura, Studley Ruth, Walker Ann Sarah, Golubchik Tanya, Lythgoe Katrina
Abstract excerpt
BACKGROUND: Persistent SARS-CoV-2 infections in hospitalised immunocompromised individuals are known to facilitate accelerated within-host viral evolution, potentially contributing to the emergence of highly divergent variants. However, little is known about the evolutionary dynamics and transmission risks of persistent infections in the general population. We aimed to characterise the within-host evolution of...
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