Article

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

2020-02-24

Abstract excerpt

HIV-1 must replicate in cells that are equipped to defend themselves from infection through intracellular innate immune systems. HIV-1 evades innate immune sensing through encapsidated DNA synthesis and encodes accessory genes that antagonize specific antiviral effectors. Here we show that both particle associated, and expressed HIV-1 Vpr, antagonize the stimulatory effect of a variety of pathogen associated molec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0ccf864f-0022-5273-9007-fd5d1fa18261
DOI: 10.1101/2020.02.22.960757

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transportDOI 10.1101/2020.02.22.960757Read

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infectionSemantic proximity Read

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrestSemantic proximity Read

HIV-1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic interventionSemantic proximity Read

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrestSemantic proximity Read

HIV-1 Vprâ€”a still â€œenigmatic multitaskerâ€Semantic proximity Read

HIV-1 viral protein R (Vpr) regulates viral replication and cellular proliferation in T cells and monocytoid cells in vitroSemantic proximity Read

Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophagesSemantic proximity Read

Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus ReplicationSemantic proximity Read

Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr?Semantic proximity Read

Illuminating the Role of Vpr in HIV Infection of Myeloid CellsSemantic proximity Read

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infectionSemantic proximity Read

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear PhagocytesSemantic proximity Read