Article

Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages

2020-04-13

Abstract excerpt

<h4>Summary</h4> In order to replicate, the Human Immunodeficiency Virus (HIV-1) reverse transcribes its RNA genome into DNA, which subsequently integrates into host cell chromosomes. These two key events of the viral life cycle are commonly viewed as separate not only in time but also in cellular space, since reverse transcription (RT) is thought to be completed in the cytoplasm before nuclear import and integra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e83acd1-f304-573f-a480-70c6104355f4
DOI: 10.1101/2020.04.12.038067

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophagesDOI 10.1101/2020.04.12.038067Read

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsidSemantic proximity Read

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complexSemantic proximity Read

Nuclear Import of the Pre-Integration Complex (PIC): The Achilles Heel of HIV ?Semantic proximity Read

The Spatial Organization of DNA Virus Genomes in the NucleusSemantic proximity Read

Macrophages and HIV-1Semantic proximity Read

HIV-1 Gag colocalizes with euchromatin histone marks at the nuclear peripherySemantic proximity Read

Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human MacrophagesSemantic proximity Read

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA IntegrationSemantic proximity Read

Incorporation of genome-bound cellular proteins into HIV-1 particles regulates viral infectionSemantic proximity Read

Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatinSemantic proximity Read

HIV-1 uncoats in the nucleus near sites of integrationSemantic proximity Read

Mechanisms of HIV Transcriptional Regulation and Their Contribution to LatencySemantic proximity Read