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Article

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection

1 Jul 2016

Abstract excerpt

The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription. We hence hypothesized that Vpr might be a determinant of non-activated T-cell infection. Virion-delivered Vpr activated nuclear factor of activated T cells (NFAT) through Ca(2+) influx and interference...

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PMID: 27383627
DOI: 10.1098/rsob.160046

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