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Article

Dissecting the genetic overlap between severe mental disorders and markers of cellular aging: Identification of pleiotropic genes and druggable targets.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2024

Pisanu Claudia, Congiu Donatella, Meloni Anna, Paribello Pasquale, Patrinos George P, Severino Giovanni, Ardau Raffaella, Chillotti Caterina, Manchia Mirko, Squassina Alessio

Abstract excerpt

Patients with severe mental disorders such as bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD) show a substantial reduction in life expectancy, increased incidence of comorbid medical conditions commonly observed with advanced age and alterations of aging hallmarks. While severe mental disorders are heritable, the extent to which genetic predisposition might contribute to accelerated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38402365
DOI: 10.1038/s41386-024-01822-5
PMCID: PMC11039620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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