Article
An Investigation of Psychosis Subgroups With Prognostic Validation and Exploration of Genetic Underpinnings: The PsyCourse Study.
JAMA psychiatry - 1 May 2020
Dwyer Dominic B, Kalman Janos L, Budde Monika, Kambeitz Joseph, Ruef Anne, Antonucci Linda A, Kambeitz-Ilankovic Lana, Hasan Alkomiet, Kondofersky Ivan, Anderson-Schmidt Heike, Gade Katrin, Reich-Erkelenz Daniela, Adorjan Kristina, Senner Fanny, Schaupp Sabrina, Andlauer Till F M, Comes Ashley L, Schulte Eva C, Klöhn-Saghatolislam Farah, Gryaznova Anna, Hake Maria, Bartholdi Kim, Flatau-Nagel Laura, Reitt Markus, Quast Silke, Stegmaier Sophia, Meyers Milena, Emons Barbara, Haußleiter Ida Sybille, Juckel Georg, Nieratschker Vanessa, Dannlowski Udo, Yoshida Tomoya, Schmauß Max, Zimmermann Jörg, Reimer Jens, Wiltfang Jens, Reininghaus Eva, Anghelescu Ion-George, Arolt Volker, Baune Bernhard T, Konrad Carsten, Thiel Andreas, Fallgatter Andreas J, Figge Christian, von Hagen Martin, Koller Manfred, Lang Fabian U, Wigand Moritz E, Becker Thomas, Jäger Markus, Dietrich Detlef E, Scherk Harald, Spitzer Carsten, Folkerts Here, Witt Stephanie H, Degenhardt Franziska, Forstner Andreas J, Rietschel Marcella, Nöthen Markus M, Mueller Nikola, Papiol Sergi, Heilbronner Urs, Falkai Peter, Schulze Thomas G, Koutsouleris Nikolaos
Abstract excerpt
Importance: Identifying psychosis subgroups could improve clinical and research precision. Research has focused on symptom subgroups, but there is a need to consider a broader clinical spectrum, disentangle illness trajectories, and investigate genetic associations. Objective: To detect psychosis subgroups using data-driven methods and examine their illness courses over 1.5 years and polygenic scores for...
Topics
Join the communities discussing this publication.