Article

The transcriptome of acute dehydration in Myeloid Leukemia cells

2022-09-23

Abstract excerpt

Live human myeloid leukemia (HL-60/S4) cells exposed to acute hyperosmotic stress with sucrose undergo dehydration and cell shrinkage. Interphase chromatin and mitotic chromosomes congeal, and exhibit altered phase separation (demixing) of chromatin-associated proteins. To investigate concurrent changes in the transcriptome, we exposed exponentially growing HL-60/S4 cells to acute hyperosmotic stress (∼600 milliOs...

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Literature Corpus work: 0cb55c17-f130-5c30-a4b6-df1035464f62
DOI: 10.1101/2022.09.23.509183

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