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Article

Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells.

American journal of physiology. Renal physiology - 1 Nov 2002

Chakravarty Devulapalli, Cai Qi, Ferraris Joan D, Michea Luis, Burg Maurice B, Kültz Dietmar

Abstract excerpt

Mammalian renal inner medullary (IM) cells routinely face and resist hypertonic stress. Such stress causes DNA damage to which IM cells respond with cell cycle arrest. We report that three growth arrest and DNA damage-inducible 45 (GADD45) isoforms (GADD45alpha, GADDD45beta, and GADD45gamma) are induced by acute hypertonicity in murine IM cells. Maximum induction occurs 16-18 h after the onset of hypertonicity....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12372778
DOI: 10.1152/ajprenal.00118.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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