Article

Genetic variation supports a causal role for valproate in prevention of ischemic stroke

2023-02-22

Abstract excerpt

Valproate is a candidate for ischemic stroke prevention due to its anti-atherosclerotic effects in vivo. Although valproate use is associated with decreased ischemic stroke risk in observational studies, confounding by indication precludes causal conclusions. To overcome this limitation, we applied Mendelian randomization to determine whether genetic variants that influence seizure response among valproate users a...

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Literature Corpus work: 0cab1e26-9159-554e-aee5-0a75f8ca5340
DOI: 10.1101/2023.02.14.23285856

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