Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation supports a causal role for valproate in prevention of ischemic stroke.

International journal of stroke : official journal of the International Stroke Society - 1 Jan 2024

Mayerhofer Ernst, Parodi Livia, Narasimhalu Kaavya, Wolking Stefan, Harloff Andreas, Georgakis Marios K, Rosand Jonathan, Anderson Christopher D

Abstract excerpt

BACKGROUND: Valproate is a candidate for ischemic stroke prevention due to its anti-atherosclerotic effects in vivo. Although valproate use is associated with decreased ischemic stroke risk in observational studies, confounding by indication precludes causal conclusions. AIMS: We applied Mendelian randomization to determine whether genetic variants that influence seizure response among valproate users associate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epilepsy
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ischemic Stroke

Share to Mendelian Randomization Analysis

Share to Risk Factors

Share to Seizures

Share to Stroke

Share to Valproic Acid

Source

Identifiers

PMID: 37489815
DOI: 10.1177/17474930231190259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation supports a causal role for valproate in prevention of ischemic stroke.PMID 37489815Read ↗

Genetic variation supports a causal role for valproate in prevention of ischemic strokeSemantic proximity Read ↗

Genetically predicted on-statin LDL response is associated with higher intracerebral hemorrhage riskSemantic proximity Read ↗

Mendelian Randomization Studies in Stroke: Exploration of Risk Factors and Drug Targets With Human Genetic Data.Semantic proximity Read ↗

Pharmacogenomics in Stroke and Cardiovascular Disease: State of the ArtSemantic proximity Read ↗

Association of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors.Semantic proximity Read ↗

Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study.Semantic proximity Read ↗

Leveraging Mendelian randomization to inform drug discovery and development for ischemic strokeSemantic proximity Read ↗

Genetically-Determined Low-density Lipoprotein in Ischemic Stroke SurvivorsSemantic proximity Read ↗

Repurposing drugs for the prevention of vascular dementia: Evidence from drug target Mendelian randomizationSemantic proximity Read ↗

Optimizing treatment of cardiovascular risk factors in cerebral small vessel disease using geneticsSemantic proximity Read ↗

LDL-c Lowering, Ischemic Stroke, and Small Vessel Disease Brain Imaging Biomarkers: A Mendelian Randomization StudySemantic proximity Read ↗

Stroke Genetics: Turning Discoveries into Clinical Applications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.