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Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke

4 Dec 2024

Abstract excerpt

Discovery and development of efficacious and safe pharmacological therapies is fraught with challenges. As proteins constitute the majority of drug targets and are encoded by genes, naturally occurring genetic variation within populations can provide valuable insights to inform drug discovery and development efforts. The drug target Mendelian randomization (MR) paradigm leverages these principles to investigate...

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PMID: 39628323
DOI: 10.1177/0271678x241305916

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