Article

Antibiotic usage promotes the evolution of resistance against gepotidacin, a novel multi-targeting drug

2018-12-13

Abstract excerpt

Multi-targeting antibiotics, i.e. single compounds capable to inhibit two or more bacterial targets offer a promising therapeutic strategy, but information on resistance evolution against such drugs is scarce. Gepotidacin is an antibiotic candidate that selectively inhibits both bacterial DNA gyrase and topoisomerase IV. In a susceptible organism, Klebsiella pneumoniae , a combination of two specific mutations in...

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Literature Corpus work: 0c9cb615-db04-5f26-b72c-2f6b2c755b61
DOI: 10.1101/495630

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