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Article

Prediction by modeling that epilepsy may be caused by very small functional changes in ion channels.

Archives of neurology - 1 Oct 2009

Thomas Evan A, Reid Christopher A, Berkovic Samuel F, Petrou Steven

Abstract excerpt

OBJECTIVE: To use computer simulation to perform a "genetic sensitivity" analysis to predict which genes are best positioned to increase risk as well as to predict functionally how variants in these genes might increase network excitability. METHODS: A previously published, biophysically realistic model of the dentate gyrus that included mossy fiber sprouting between granule cells was used to model putative...

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Identifiers

PMID: 19822777
DOI: 10.1001/archneurol.2009.219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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