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Production of a genetically encoded biosensor for evaluating enterovirus 71 3C protease inhibitors

28 Feb 2025

Abstract excerpt

Enterovirus 71 (EV-71) is a major causative agent of hand, foot, and mouth disease (HFMD), which mainly affects infants and children. However, there are no effective clinical drugs for the treatment of HFMD. The 3C protease (3Cpro) is an ideal drug target for antivirals, as this enzyme plays an indispensable role in virus replication. Considering the limitations of the peptide substrates used in the fluorescence...

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PMID: 40018827
DOI: 10.1080/10826068.2025.2472952

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