Article

A small molecule RIG-I agonist serves to adjuvant broad multifaceted influenza virus vaccine immunity

2022-09-20

Abstract excerpt

Retinoic acid-inducible gene I (RIG-I) is essential for activating host cell innate immunity to regulates the immune response against many RNA viruses. We identified a small molecule compound, KIN1148, that directly binds RIG-I to drive IRF3activation to impart the expression of IRF3-target genes, including specific immunomodulatory cytokines and chemokines. KIN1148 does not lead to ATPase activity or compete with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c685658-c6bb-5d01-b0c0-eecd716209ff
DOI: 10.1101/2022.09.20.508779

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A small molecule RIG-I agonist serves to adjuvant broad multifaceted influenza virus vaccine immunityDOI 10.1101/2022.09.20.508779Read

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR PathwaySemantic proximity Read

Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine designSemantic proximity Read

TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells <i>in vitro</i> and generate unique cellular immune responses in influenza vaccinationSemantic proximity Read

Evolving A RIG-I Antagonist: A Modified DNA Aptamer Mimics Viral RNA.Semantic proximity Read

A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in miceSemantic proximity Read

Broad-spectrum antiviral inhibitors targeting pandemic potential RNA virusesSemantic proximity Read

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate ImmunitySemantic proximity Read

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19Semantic proximity Read

Broad-spectrum RNA antiviral inspired by ISG15 <sup>-/-</sup> deficiencySemantic proximity Read

Coexpressed RIG-I Agonist Enhances Humoral Immune Response to Influenza Virus DNA VaccineSemantic proximity Read

Influenza A Infection Stimulates RIG-I and Enhances Effector Function of Primary Human NK CellsSemantic proximity Read

Influenza Viruses Control the Vertebrate Type I Interferon System: Factors, Mechanisms, and ConsequencesSemantic proximity Read