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Genetic Targeting of the dTORC1 Inhibitor, dSAMTOR, during <em>Drosophila</em> Aging: A Tissue-specific Pathology

2023-05-08

Abstract excerpt

mTORC1 regulates mammalian cell metabolism and growth, in response to diverse environmental stimuli. Nutrient signals control the localization of mTORC1 onto lysosome-surface scaffolds that are critically implicated in its amino acid-dependent activation. Arginine, Leucine and S-Adenosyl-Methionine (SAM) can serve as major mTORC1-signaling activators, with SAM binding to SAMTOR (SAM + TOR), a fundamental SAM senso...

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Identifiers and source

Literature Corpus work
58773eef-490e-5e45-b1ee-9db60b90bcda
DOI
10.20944/preprints202305.0538.v1
Open publication

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