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The Skin Barrier: A System Driven by Phase Separation

2025-08-07

Abstract excerpt

The mammalian epidermis forms a critical barrier against environmental insults and water loss. The formation of its outermost layer, the stratum corneum, involves a rapid terminal differentiation process that has traditionally been explained by the "bricks and mortar" model. Recent advances reveal a more dynamic mechanism governed by intra-cellular liquid-liquid phase separation (LLPS). This review propo...

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Literature Corpus work
0c2481f4-1b5b-5e43-8a5e-740b557470d4
DOI
10.20944/preprints202508.0569.v1
Open publication

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The Skin Barrier: A System Driven by Phase SeparationDOI 10.20944/preprints202508.0569.v1
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