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Article

Orchestrated control of filaggrin–actin scaffolds underpins cornification

15 Mar 2018

Abstract excerpt

Epidermal stratification critically depends on keratinocyte differentiation and programmed death by cornification, leading to formation of a protective skin barrier. Cornification is dynamically controlled by the protein filaggrin, rapidly released from keratohyalin granules (KHGs). However, the mechanisms of cornification largely remain elusive, partly due to limitations of the observation techniques employed to...

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PMID: 29545605
DOI: 10.1038/s41419-018-0407-2

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