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Multivariate chemogenomic screening prioritizes new macrofilaricidal leads

2022-07-25

Abstract excerpt

Development of direct acting macrofilaricides for the treatment of human filariases is hampered by limitations in screening throughput imposed by the parasite life cycle. Efforts to circumvent arduous screening of adult filariae include drug repurposing and high-throughput screens that target commensal bacteria. In vitro adult screens typically assess single phenotypes without prior enrichment for chemicals with...

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Literature Corpus work
0c1f19ea-ae78-52c4-95dc-96a36d156a12
DOI
10.1101/2022.07.25.501423
Open publication

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Multivariate chemogenomic screening prioritizes new macrofilaricidal leadsDOI 10.1101/2022.07.25.501423
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