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Article

Deep phenotypic profiling uncovers cryptic effects of antifilarial drugs.

PLoS pathogens - 1 Jul 2026

Ryan Kaetlyn T, Dinguirard Nathalie, Henthorn Clair R, Wheeler Nicolas J, Zamanian Mostafa

Abstract excerpt

The anthelmintics ivermectin, albendazole, and diethylcarbamazine are the backbone of mass drug administration (MDA) campaigns targeting human filariasis, yet their direct effects on parasites are still not fully defined or understood. The clinical effects of these drugs are stage dependent, resulting in effective clearance of circulating microfilariae but only limited activity against adult worms, a pattern that...

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PMID: 42525707
DOI: 10.1371/journal.ppat.1014485
PMCID: PMC13436727

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