Article
An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes.
International journal for parasitology. Drugs and drug resistance - 1 Apr 2018
Partridge Frederick A, Brown Anwen E, Buckingham Steven D, Willis Nicky J, Wynne Graham M, Forman Ruth, Else Kathryn J, Morrison Alison A, Matthews Jacqueline B, Russell Angela J, Lomas David A, Sattelle David B
Abstract excerpt
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic compounds is a global threat. We have developed an INVertebrate Automated Phenotyping Platform (INVAPP) for high-throughput, plate-based chemical screening, and an...
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