Article
High-throughput phenotypic screening of Medicines for Malaria Venture's Hit Generation Library 1 identifies new nematocidal chemotypes.
International journal for parasitology. Drugs and drug resistance - 1 Apr 2026
Taki Aya C, Byrne Joseph J, Chang Bill C H, Laleu Benoît, Wells Timothy N C, Jabbar Abdul, Gasser Robin B
Abstract excerpt
Parasitic helminths impose substantial health and economic burdens on humans and livestock, and widespread resistance to existing anthelmintic classes underscores the urgent need for new chemotypes with distinct mechanisms of action as part of integrated parasite control strategies. Here, we performed a large-scale phenotypic screen of the Medicines for Malaria Venture Hit Generation Library 1 (HGL1), testing...
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