Article

ASD mutation of Katnal2 impairs ependymal ciliary motion and causes hydrocephalus

2023-07-03

Abstract excerpt

Katanin catalytic subunit A1 like 2 ( KATNAL2 ) is a high-risk gene associated with autism spectrum disorders (ASD), however its impact on brain development and disease remains unclear. The present study revealed an unexpected role of KATNAL2 in regulating ependymal ciliary motion and cerebrospinal fluid flow during brain development, an important contributing factor for ASD. We discovered a distinct expression p...

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Literature Corpus work: 0c122f7b-8210-56fd-a3ab-d6e83593ef99
DOI: 10.1101/2023.07.03.547302

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