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Article

Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice.

PLoS biology - 1 May 2024

Kang Ryeonghwa, Kim Kyungdeok, Jung Yewon, Choi Sang-Han, Lee Chanhee, Im Geun Ho, Shin Miram, Ryu Kwangmin, Choi Subin, Yang Esther, Shin Wangyong, Lee Seungjoon, Lee Suho, Papadopoulos Zachary, Ahn Ji Hoon, Koh Gou Young, Kipnis Jonathan, Kang Hyojin, Kim Hyun, Cho Won-Ki, Park Soochul, Kim Seong-Gi, Kim Eunjoon

Abstract excerpt

Autism spectrum disorders (ASD) frequently accompany macrocephaly, which often involves hydrocephalic enlargement of brain ventricles. Katnal2 is a microtubule-regulatory protein strongly linked to ASD, but it remains unclear whether Katnal2 knockout (KO) in mice leads to microtubule- and ASD-related molecular, synaptic, brain, and behavioral phenotypes. We found that Katnal2-KO mice display ASD-like social...

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Identifiers

PMID: 38718086
DOI: 10.1371/journal.pbio.3002596
PMCID: PMC11104772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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