Article

Membrane curvature-generating proteins crucial for autophagosome formation

2022-10-27

Abstract excerpt

Autophagy is essential for cellular homeostasis and begins with the formation of a phagophore, a cup-like membrane sheet consisting of two closely apposed lipid bilayers connected by a highly curved rim. How the membrane sheet forms, bends, and eventually generates an autophagosome that enwraps cargo remains enigmatic. Specifically, it is unclear how the high membrane curvature of the phagophore rim, an energetica...

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Literature Corpus work: 0c06da33-ace4-53d9-9a19-93172cf64826
DOI: 10.1101/2022.10.27.514035

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