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Article

Mechanism of membrane-curvature generation by ER-tubule shaping proteins.

Nature communications - 25 Jan 2021

Wang Ning, Clark Lindsay D, Gao Yuan, Kozlov Michael M, Shemesh Tom, Rapoport Tom A

Abstract excerpt

The endoplasmic reticulum (ER) network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs. These proteins have two pairs of trans-membrane (TM) segments, followed by an amphipathic helix (APH), but how they induce curvature is poorly understood. Here, we show that REEPs form homodimers by interaction within the membrane. When overexpressed or reconstituted at...

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Identifiers

PMID: 33495454
DOI: 10.1038/s41467-020-20625-y
PMCID: PMC7835363

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