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Article

The autophagy-specific exocyst subcomplex contributes to phagophore assembly site integrity by promoting phagophore expansion.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2025

Kumari Ruchika, Nath Titikhya, Pflaum Jeremy, R Inchara, Vinay Sannannagari, Wilfling Florian, Manjithaya Ravi

Abstract excerpt

Autophagy is a crucial intracellular pathway for maintaining cellular homeostasis. It involves forming double-membrane vesicles called autophagosomes, which deliver cytosolic cargoes to the lysosomes/vacuoles for degradation. Biogenesis of autophagosomes is a membrane-intensive process wherein the membrane expansion steps are poorly understood. The tethering complex, exocyst, canonically implicated in secretion,...

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Identifiers

PMID: 41055993
DOI: 10.1073/pnas.2426476122
PMCID: PMC12541320

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