Article

Olfactory biopsy analysis of Alzheimer’s pathobiology across disease stages

2025-11-12

Abstract excerpt

Alzheimer’s Disease (AD) is a neurodegenerative condition affecting millions worldwide. Defining early pathobiological events remains challenging, in part due to inaccessibility of neural tissue. Because olfactory neurons are accessible, and olfactory loss is prevalent in AD, we evaluated olfactory brush biopsies from controls, individuals with cerebrospinal fluid (CSF) biomarker-confirmed AD, and cognitively typi...

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Literature Corpus work: 0c031b97-e869-5e98-a8de-402ef1373b60
DOI: 10.1101/2025.11.11.687356

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