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Clinical presentation and differential splicing of<i>SRSF2, U2AF1</i>and<i>SF3B1</i>mutations in patients with Acute Myeloid Leukaemia

2020-01-10

Abstract excerpt

Previous studies demonstrated that splicing factor mutations are recurrent events in hematopoietic malignancies with both clinical and functional implications. However, their aberrant splicing patterns in acute myeloid leukaemia remain largely unexplored. In this study we characterized mutations in SRSF2, U2AF1 and SF3B1 , the most commonly mutated splicing factors. In our clinical analysis of 2678 patients, splic...

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Literature Corpus work
0be97c4a-df3d-5ade-8467-950c70fb6083
DOI
10.1101/2020.01.07.20016881
Open publication

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Clinical presentation and differential splicing of<i>SRSF2, U2AF1</i>and<i>SF3B1</i>mutations in patients with Acute Myeloid LeukaemiaDOI 10.1101/2020.01.07.20016881
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