Article

Deep Mutational Scan of a cardiac sodium channel voltage sensor

2019-09-18

Abstract excerpt

Variants in ion channel genes have classically been studied in low-throughput by patch clamping. Deep Mutational Scanning (DMS) is a complementary approach that can simultaneously assess function of thousands of variants. We have developed and validated a method to perform a DMS of variants in SCN5A , which encodes the major voltage-gated sodium channel in the heart. We created a library of nearly all possible va...

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Literature Corpus work: a84a5770-b527-5162-ab35-00a6b6968132
DOI: 10.1101/773887

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