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Article

Deep Mutational Scan of an SCN5A Voltage Sensor.

Circulation. Genomic and precision medicine - 1 Feb 2020

Glazer Andrew M, Kroncke Brett M, Matreyek Kenneth A, Yang Tao, Wada Yuko, Shields Tiffany, Salem Joe-Elie, Fowler Douglas M, Roden Dan M

Abstract excerpt

BACKGROUND: Variants in ion channel genes have classically been studied in low throughput by patch clamping. Deep mutational scanning is a complementary approach that can simultaneously assess function of thousands of variants. METHODS: We have developed and validated a method to perform a deep mutational scan of variants in SCN5A, which encodes the major voltage-gated sodium channel in the heart. We created a...

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Identifiers

PMID: 31928070
DOI: 10.1161/CIRCGEN.119.002786
PMCID: PMC7031040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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