Article

Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function

2023-10-06

Abstract excerpt

Amino acid insertions and deletions (indels) are an abundant class of genetic variants. However, compared to substitutions, the effects of indels on protein stability are not well understood and are poorly predicted. To better understand indels here we analyze new and existing large-scale deep indel mutagenesis (DIM) of structurally diverse proteins. The effects of indels on protein stability vary extensively amon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5bdc993e-cb93-5a0f-be50-dd92129b80e4
DOI: 10.1101/2023.10.06.561180

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and functionDOI 10.1101/2023.10.06.561180Read

Elucidating the Structural Impacts of Protein InDels.Semantic proximity Read

DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology.Semantic proximity Read

Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation.Semantic proximity Read

Insertions and deletions in protein evolution and engineering.Semantic proximity Read

Exploring amino acid functions in a deep mutational landscape.Semantic proximity Read

Uncovering differential tolerance to deletions versus substitutions with a protein language modelSemantic proximity Read

The effects of non-synonymous single nucleotide polymorphisms (nsSNPs) on protein-protein interactions.Semantic proximity Read

News from the protein mutability landscape.Semantic proximity Read

SNAP predicts effect of mutations on protein function.Semantic proximity Read

Protein expansion is primarily due to indels in intrinsically disordered regions.Semantic proximity Read

A comprehensive study of small non-frameshift insertions/deletions in proteins and prediction of their phenotypic effects by a machine learning method (KD4i).Semantic proximity Read

Decoding molecular mechanisms for loss-of-function variants in the human proteomeSemantic proximity Read