Article

Application of CRISPR/Cas9-based mutant enrichment technique to improve the clinical sensitivity of plasma EGFR testing in patients with non-small cell lung cancer

2021-09-28

Abstract excerpt

<h4>Background: </h4> Mutation detection in cell-free DNA (cfDNA) has increased and is becoming important in the field of precision medicine. Highly fragmented, low-quantity circulating tumor DNA is an obstacle for detecting mutations. Therefore, more sensitive mutation detection techniques are required. Here, we report a new mutant enrichment technology, the CRISPR system combined with post-polymerase chain react...

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Literature Corpus work: 0bb44d85-7c0b-5716-ac33-5beb65d0ad6d
DOI: 10.21203/rs.3.rs-927246/v1

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