Article
Detection and Monitoring of Tumor-Derived Mutations in Circulating Tumor DNA Using the UltraSEEK Lung Panel on the MassARRAY System in Metastatic Non-Small Cell Lung Cancer Patients.
International journal of molecular sciences - 29 Aug 2023
Leest Paul van der, Janning Melanie, Rifaela Naomi, Azpurua Maria L Aguirre, Kropidlowski Jolanthe, Loges Sonja, Lozano Nicolas, Sartori Alexander, Irwin Darryl, Lamy Pierre-Jean, Hiltermann T Jeroen N, Groen Harry J M, Pantel Klaus, Kempen Léon C van, Wikman Harriet, Schuuring Ed
Abstract excerpt
Analysis of circulating tumor DNA (ctDNA) is a potential minimally invasive molecular tool to guide treatment decision-making and disease monitoring. A suitable diagnostic-grade platform is required for the detection of tumor-specific mutations with high sensitivity in the circulating cell-free DNA (ccfDNA) of cancer patients. In this multicenter study, the ccfDNA of 72 patients treated for advanced-stage...
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