Article

COMMD10-deficiency in adipose tissue macrophages attenuates obesity and insulin resistance by boosting mitochondrial and antioxidant functions

2024-06-06

Abstract excerpt

<title>Abstract</title> <p>During obesity, adipose tissue macrophages (ATM) colonize the white adipose tissue (WAT), where they acquire metabolically activated phenotypes. Here, we demonstrate that COMMD10 is a key regulator of macrophage oxidative capacity in response to chronic caloric excess. Mice with COMMD10-deficiency targeted to macrophages fed high-fat-diet (HFD) gained less weight, showed improved serum...

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Literature Corpus work: 6b81ba7e-781c-5cc9-9ecc-3bd152070c2d
DOI: 10.21203/rs.3.rs-3891148/v1

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