Article

BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive dysfunction (RICD). RICD significantly impacts the quality of life for cancer survivors, highlighting an unmet medical need. Previous human studies revealed a marked reduction in plasma brain-derived neurotrophic factor (BDNF) post-chronic chemotherapy, linking this decline to...

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Literature Corpus work: 0b763b75-1e29-5aaa-a744-99b0f291673e
DOI: 10.1101/2024.09.23.614590

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