Article

M102, a combined NRF2 and HSF-1 activator for neuroprotection in amyotrophic lateral sclerosis

2024-12-14

Abstract excerpt

M102 is a central nervous system (CNS) penetrant small molecule electrophile which activates in vivo the NFE2-related factor 2 antioxidant response element (NRF2-ARE) pathway, as well as transcription of heat-shock element (HSE) associated genes. In the TDP-43 Q331K transgenic mouse model of ALS dosed subcutaneously at 5mg/kg OD or 2.5mg/kg BD with M102, significant improvements in compound muscle action potenti...

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Literature Corpus work: 0b661dc4-fdbe-595e-8d07-25b885164045
DOI: 10.1101/2024.12.08.627389

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