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The epigenome of Trypanosoma brucei: A regulatory interface to an unconventional transcriptional machine

3 Jun 2014

Abstract excerpt

The epigenome represents a major regulatory interface to the eukaryotic genome. Nucleosome positions, histone variants, histone modifications and chromatin associated proteins all play a role in the epigenetic regulation of DNA function. Trypanosomes, an ancient branch of the eukaryotic evolutionary lineage, exhibit some highly unusual transcriptional features, including the arrangement of functionally unrelated...

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PMID: 24942804
DOI: 10.1016/j.bbagrm.2014.05.028

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