Article

Non-neuronal, TGF-β–driven extracellular matrix restructuring promotes neurodegeneration in a PSP-Richardson syndrome model

2025-08-18

Abstract excerpt

Progressive supranuclear palsy–Richardson syndrome (PSP-RS) is a rapidly progressive tauopathy lacking effective therapies. Although tau aggregation is a defining feature, the initiating mechanisms remain elusive. Here we used patient-derived induced pluripotent stem cell midbrain organoids, integrating single-cell transcriptomics, bulk RNA profiling, and quantitative proteomics, to dissect early pathogenic events...

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Literature Corpus work: 0b276563-ceab-53c4-b01e-802f9c7fd4f9
DOI: 10.1101/2025.08.17.670724

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