Article

Extracellular matrix remodeling links vascular–stromal dysfunction to neuronal tau pathology in Progressive Supranuclear Palsy

2025-11-10

Abstract excerpt

<title>Abstract</title> <p>Progressive supranuclear palsy-Richardson’s syndrome (PSP-RS) is a primary tauopathy lacking disease-modifying treatments, and the pathogenic mechanisms remain poorly understood. Here, combining patient-derived midbrain organoids with single-cell and bulk transcriptomics, quantitative proteomics, and functional assays, we identified extracellular matrix (ECM) dysregulation as an early p...

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Literature Corpus work: 2582019a-f376-5b91-ae50-267bcc5dc192
DOI: 10.21203/rs.3.rs-7956425/v1

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