Article
The Molecular Impact of Glucosylceramidase Beta 1 (Gba1) in Parkinson's Disease: a New Genetic State of the Art.
Molecular neurobiology - 1 Sept 2024
Dos Santos Júlio César Claudino, Mano Gabriela Braga Cabrera, da Cunha Barreto-Vianna André Rodrigues, Garcia Tulia Fernanda Meira, de Vasconcelos Aline Vieira, Sá Caio Sérgio Gomes, de Souza Santana Sarah Lopes, Farias Ana Gabriela Ponte, Seimaru Beatriz, Lima Micael Porto Portela, Goes João Vitor Caetano, Gusmão Camilla Teixeira Pinheiro, Junior Howard Lopes Ribeiro
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative disorder affecting 2-3% of those aged over 65, characterized by motor symptoms like slow movement, tremors, and muscle rigidity, along with non-motor symptoms such as anxiety and dementia. Lewy bodies, clumps of misfolded proteins, contribute to neuron loss in PD. Mutations in the GBA1 gene are considered the primary genetic risk factor of PD. GBA1 mutations result...
Topics
- Humans
- Glucosylceramidase
- Parkinson Disease
- Mutation
- Animals
- Genetic Predisposition to Disease
- alpha-Synuclein