Article
Mutations in the glucocerebrosidase gene are responsible for Chinese patients with Parkinson's disease.
Journal of human genetics - 1 Feb 2015
Yu Zhe, Wang Ting, Xu Jun, Wang Wei, Wang Guifang, Chen Chao, Zheng Lili, Pan Li, Gong Dianrong, Li Xueli, Qu Huaiqian, Li Fang, Zhang Bin, Le Weidong, Han Fabin
Abstract excerpt
Pathological mutations in the glucocerebrosidase gene (GBA) have been suggested to be associated with Parkinson's disease (PD) in various ethnic populations. Most studies on Chinese PD patients have only screened the N370S and L444P mutations in the GBA gene. To investigate the GBA mutations in Chinese population, we performed complete sequencing of the GBA gene in 184 Chinese PD patients and 130 Chinese control...
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