Article

<i>GALC</i>variants affect galactosylceramidase enzymatic activity and risk of Parkinson’s disease

2022-05-03

Abstract excerpt

The association between glucocerebrosidase (GCase), encoded by GBA , and Parkinson’s disease highlights the role of the lysosome in Parkinson’s disease pathogenesis. Genome-wide association studies (GWAS) in Parkinson’s disease have revealed multiple associated loci, including the GALC locus on chromosome 14. GALC encodes the lysosomal enzyme galactosylceramidase (GalCase), which plays a pivotal role in the glycos...

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Literature Corpus work: cff14b87-6ad2-5c8f-9336-4da1e23ee196
DOI: 10.1101/2022.04.30.22274239

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