Article

IL-17 axis is a significant driver of skin inflammation in Card14 mutant pityriasis rubra pilaris model mice

2023-02-02

Abstract excerpt

<title>Abstract</title> <p>Pityriasis rubra pilaris (PRP) is a rare inflammatory keratinization disorder with perifollicular erythema, and most autosomal dominant familial cases of atypical juvenile (type V) PRP are caused by gain-of-function mutations in CARD14, which encodes caspase recruitment domain-containing protein 14 (CARD14). We report the first mouse model of PRP to carry a homozygous knock-in mutation,...

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Literature Corpus work: 0b1c6e2f-56ee-5371-bc8d-f2e2d1fec5f5
DOI: 10.21203/rs.3.rs-2513325/v1

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