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Article

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.

Trends in immunology - 1 Apr 2013

Lowes Michelle A, Russell Chris B, Martin David A, Towne Jennifer E, Krueger James G

Abstract excerpt

Psoriasis is a complex inflammatory process resulting from activation of the well-defined interleukin (IL)-23/T17 cytokine axis. We review the role of key cytokines IL-17 and IL-23 in psoriasis, as well as tumor necrosis factor (TNF)α, focusing on therapeutic cytokine interventions and what they reveal about psoriatic inflammation. The potential role of recently described epidermal IL-36RN and CARD14 genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23291100
DOI: 10.1016/j.it.2012.11.005
PMCID: PMC3721313

Genes

CARD14
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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