Beneficial effect of ustekinumab in familial pityriasis rubra pilaris with a new missense mutation in CARD14

Abstract excerpt

Pityriasis rubra pilaris (PRP) represents a group of rare chronic inflammatory skin disorders in which around one in 20 affected individuals show autosomal dominant inheritance. In such cases there may be gain-of-function mutations in CARD14, encoding caspase recruitment domain-containing protein 14 (CARD14), which activates the noncanonical nuclear factor (NF)-κB pathway, thereby promoting cutaneous...

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• Dermatology and Skin Diseases
• NF-κB Signaling Pathways
• Psoriasis: Treatment and Pathogenesis